08.06.2020 Biotest AG  DE0005227235

DGAP-News: Biotest AG: Biotest's Zutectra(R) demonstrates improved quality of life in a study with liver transplant patients


DGAP-News: Biotest AG / Key word(s): Research Update
Biotest AG: Biotest's Zutectra(R) demonstrates improved quality of life in a study with liver transplant patients

08.06.2020 / 07:00
The issuer is solely responsible for the content of this announcement.


Biotest's Zutectra(R) demonstrates improved quality of life in a study with liver transplant patients

- Zutectra(R) offers convenient home therapy option for high risk Hepatitis B induced liver transplant patients during COVID-19 pandemic

- Zutectra(R) is the only Hepatitis B immunoglobulin product worldwide for self-administration at home

- New data of a multicentre observational study reveal improved quality of life with Zutectra compared to other applications forms

- Zutectra demonstrated significant improvement in pain reduction and increased patient convenience

- Study results support positive commercial outlook

Dreieich, 8 June 2020. Home care therapy with Zutectra(R) is a valuable option for liver transplant (LT) patients, especially during the current COVID-19 pandemic. Patients are not required to visit the hospital and remain independent from contacts with medical professionals. This minimizes contacts and the risk of infection in these immunosuppressed patients, while keeping them on therapy to prevent Hepatitis B recurrence.

Zutectra(R) is the worldwide only subcutaneous (SC) Hepatitis B immunoglobulin (HBIG) product and was developed to provide a convenient option for outpatient therapy. The preference of SC over intramuscular (IM) and intravenous (IV) application forms was confirmed by a recently published study in the Journal "Health and Quality of Life Outcomes".[1]

The multicentre, observational study was conducted in nine LT centres in Italy including 86 patients. Previously to inclusion into the study liver transplanted patients have been on IV or IM HBIG therapy for at least 6 month before switching to Zutectra(R). Two validated quality of life questionnaires evaluating different categories of technical aspects of therapy as well as mental and physical conditions have been used before and 6 months after switching to Zutectra(R).

Zutectra(R) demonstrated significant improvements in most of the tested domains, such as side effects, satisfaction with the HBIG therapy, pain, physical functioning, physical and emotional role limitations, and social functioning.

The authors concluded: "The striking improvement in treatment satisfaction further suggests that SC HBIG can represent the treatment of choice for most LT patients."
Biotest sees an opportunity to expand market share, through switching patients to the only subcutaneous HBIG in the current COVID-19 pandemic and beyond.

About Zutectra(R)
Zutectra(R) was specifically developed by Biotest for the long-term treatment of patients after liver transplantation preventing hepatitis B virus re-infection. It is worldwide the first ready-to-use hepatitis B immunoglobulin solution in a pre-filled syringe for subcutaneous administration and it gives patients the opportunity of self-administration. This provides the attending physicians and patients with a less-painful, time-saving and simpler treatment option. The European Commission has granted marketing approval to Biotest for the hepatitis B immunoglobulin Zutectra(R) in 2009. Zutectra(R) is currently marketed in the EU member states and major ROW markets.

About Hepatect(R) CP
Hepatect(R) CP is a hepatitis B virus (HBV)-specific hyperimmunoglobulin preparation. Approved in over 35 countries Hepatect(R) CP is one of the leading HBV immunoglobulin brands worldwide. It is indicated for the prevention of HBV re-infection after liver transplantation and for immunoprophylaxis of HBV infection. Prophylaxis of HBV infection may be required in case of accidental exposure in non-immunised subjects (e.g. needle stick injury), in haemodialysis patients, until vaccination has become effective, in the newborn of a hepatitis B virus carrier-mother, and in subjects who did not show an immune response after vaccination. Hepatect(R) CP is available as ready-to-use solution for intravenous administration.

About Biotest
Biotest is a provider of plasma proteins and biological drugs. With a value added chain that extends from pre-clinical and clinical development to worldwide sales, Biotest has specialised primarily in the areas of clinical immunology, haematology and intensive care medicine. Biotest develops and markets immunoglobulins, coagulation factors and albumin based on human blood plasma. These are used for diseases of the immune and haematopoietic systems. Biotest has more than 1,800 employees worldwide. The ordinary and preference shares of Biotest AG are listed in the Prime Standard on the German stock exchange.

IR contact
Dr Monika Buttkereit
Phone: +49-6103-801-4406
Mail: [email protected]

PR contact
Dirk Neumüller
Phone: +49-6103-801-269
Mail: [email protected]

Biotest AG, Landsteinerstr. 5, 63303 Dreieich, Germany, www.biotest.com

Ordinary shares: securities' ID No. 522720; ISIN DE0005227201
Preference shares: securities' ID No. 522723; ISIN DE0005227235
Listing: Frankfurt (Prime Standard)
Open Market: Berlin, Düsseldorf, Hamburg/ Hanover, Munich, Stuttgart, Tradegate

This document contains forward-looking statements on overall economic development as well as on the business, earnings, financial and assets position of Biotest AG and its subsidiaries. These statements are based on current plans, estimates, forecasts and expectations of the company and are thus subject to risks and elements of uncertainty that could result in significant deviation of actual developments from expected developments. The forward-looking statements are only valid at the time of publication. Biotest does not intend to update the forward-looking statements and assumes no obligation to do so.
[1] Volpes et al., 2020, Switch from intravenous or intramuscular to subcutaneous hepatitis B immunoglobulin: effect on quality of life after liver transplantation, Health Qual Life Outcomes, 18: 99

08.06.2020 Dissemination of a Corporate News, transmitted by DGAP - a service of EQS Group AG.
The issuer is solely responsible for the content of this announcement.

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Language: English
Company: Biotest AG
Landsteinerstraße 5
63303 Dreieich
Phone: 0 61 03 - 8 01-0
Fax: 0 61 03 - 8 01-150
E-mail: [email protected]
Internet: http://www.biotest.de
ISIN: DE0005227235, DE0005227201
WKN: 522723, 522720
Listed: Regulated Market in Frankfurt (Prime Standard); Regulated Unofficial Market in Berlin, Dusseldorf, Hamburg, Hanover, Munich, Stuttgart, Tradegate Exchange
EQS News ID: 1064611

End of News DGAP News Service

1064611  08.06.2020 


Die wichtigsten Finanzdaten auf einen Blick
  2015 2016 2017 2018 2019 2020 2021e
Umsatzerlöse1 589,60 553,10 378,10 400,30 419,10 484,20 508,00
EBITDA1,2 22,40 86,60 13,00 35,20 30,50 28,30 21,50
EBITDA-Marge3 3,80 15,66 3,44 8,79 7,28 5,84 4,23
EBIT1,4 -71,80 63,90 -9,30 10,60 -1,20 -1,30 -8,00
EBIT-Marge5 -12,18 11,55 -2,46 2,65 -0,29 -0,27 -1,58
Jahresüberschuss1 -82,50 -45,70 -3,50 181,70 -4,70 -31,40 0,00
Netto-Marge6 -13,99 -8,26 -0,93 45,39 -1,12 -6,48 0,00
Cashflow1,7 38,10 65,90 34,30 -50,00 -33,60 -16,70 0,00
Ergebnis je Aktie8 -2,08 -1,17 -0,40 4,58 -0,11 -0,72 -0,65
Dividende8 0,04 0,07 0,04 0,04 0,04 0,04 0,04
Quelle: boersengefluester.de und Firmenangaben

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1 in Mio. Euro; 2 EBITDA = Ergebnis vor Zinsen, Steuern und Abschreibungen; 3 EBITDA in Relation zum Umsatz; 4 EBIT = Ergebnis vor Zinsen und Steuern; 5 EBIT in Relation zum Umsatz; 6 Jahresüberschuss (-fehlbetrag) in Relation zum Umsatz; 7 Cashflow aus der gewöhnlichen Geschäftstätigkeit; 8 in Euro; Quelle: boersengefluester.de

Wirtschaftsprüfer: Ernst & Young

Biotest VZ
WKN Kurs in € Einschätzung Börsenwert in Mio. €
522723 35,400 Halten 1.383,02
KGV 2022e KGV 10Y-Ø BGFL-Ratio Shiller-KGV
0,00 21,02 0,00 272,31
3,18 - 2,86 67,07
Dividende '19 in € Dividende '20e in € Div.-Rendite '20e
in %
0,04 0,04 0,11 11.05.2021
Q1-Zahlen Q2-Zahlen Q3-Zahlen Bilanz-PK
11.05.2021 12.08.2021 11.11.2021 31.03.2021
Abstand 60Tage-Linie Abstand 200Tage-Linie Performance YtD Performance 52 Wochen
10,22% 20,81% 25,98% 64,65%
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