30.07.2018
Fresenius Medical Care AG & Co. KGaA DE0005785802
DGAP-News: Fresenius Medical Care achieves preclinical milestone in its regenerative medicine program for chronic kidney disease
DGAP-News: Fresenius Medical Care AG & Co. KGaA / Key word(s):
Miscellaneous/Study results
Fresenius Medical Care achieves preclinical milestone in its regenerative
medicine program for chronic kidney disease
30.07.2018 / 11:43
The issuer is solely responsible for the content of this announcement.
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Fresenius Medical Care, the world's largest provider of dialysis products
and services, announced today that its subsidiary Unicyte AG has achieved a
key preclinical milestone in its regenerative medicine program for chronic
kidney disease. The company was able to confirm a disease modifying
potential for its proprietary nano-Extracellular Vesicles ("nEVs" are stem
cell-derived particles that support communication between cells) in a second
preclinical model of chronic kidney disease.
When administered to mice with fast progressing kidney disease, Unicyte's
nEVs prevented renal fibrosis, a hallmark of chronic kidney disease. In
particular, nEVs significantly reduced interstitial fibrosis and tubular
necrosis while also inhibiting infiltration of various cells. This resulted
in near-to-normal recovery of kidney function. The study conducted in
collaboration with Prof. Giovanni Camussi of the University of Turin, Italy,
has been accepted for publication in the peer-reviewed journal Frontiers of
Immunology (https://doi.org/10.3389/fimmu.2018.01639).
These new results support previous findings in a preclinical model of slowly
progressing kidney disease (diabetic nephropathy), a major pathology that
often leads to end-stage renal disease. Combined results of these studies
demonstrate the efficacy and the underlying mechanism of action of nEVs in
preventing renal fibrosis and subsequent progression to end-stage renal
disease. Unicyte will continue the preclinical and clinical development of
its proprietary nEVs for treatment of chronic and acute kidney diseases.
Dr. Olaf Schermeier, Fresenius Medical Care's CEO for Global Research and
Development, said: "We are very excited about the progress we have made with
our research and development activities over the last 30 months since we
have established Unicyte. Based on these achievements, Unicyte will continue
to explore the potential of nEVs for the treatment of patients in
pre-dialysis stages of chronic kidney disease."
Prof. Giovanni Camussi, Professor Emeritus at the University of Turin and
Member of Unicyte's Scientific Advisory Board, said, "nEVs are a promising
regenerative medicine technology platform. Our aim is to develop new and
better treatment options for severely and chronically ill patients over
time. Achieving this preclinical milestone represents an important step
towards testing nEVs in the clinical setting."
With multiple therapeutic programs at the clinical and preclinical stage,
Unicyte has established a broad pipeline in kidney and liver diseases,
diabetes and oncology. The company is seeking strategic partnerships for its
non-renal programs.
Fresenius Medical Care is the world's largest provider of products and
services for individuals with renal diseases of which around 3.2 million
patients worldwide regularly undergo dialysis treatment. Through its network
of 3,790 dialysis clinics, Fresenius Medical Care provides dialysis
treatments for 322,253 patients around the globe. Fresenius Medical Care is
also the leading provider of dialysis products such as dialysis machines or
dialyzers. Along with its core business, the company provides related
medical services in the field of Care Coordination. Fresenius Medical Care
is listed on the Frankfurt Stock Exchange (FME) and on the New York Stock
Exchange (FMS).
For more information visit the company's website at
www.freseniusmedicalcare.com.
Unicyte AG is a regenerative medicine company with a focus on kidney & liver
disorders, diabetes and oncology. Unicyte evolved from a long-term research
collaboration of Italy's University of Turin and Fresenius Medical Care.
Unicyte is headquarted in Oberdorf NW, Switzerland, and is an independent
affiliate of Fresenius Medical Care, the world's largest provider of
products and services for individuals with renal diseases.
For more information visit the company's website at www.unicyte.ch.
Disclaimer
This release contains forward-looking statements that are subject to various
risks and uncertainties. Actual results could differ materially from those
described in these forward-looking statements due to certain factors,
including changes in business, economic and competitive conditions,
regulatory reforms, foreign exchange rate fluctuations, uncertainties in
litigation or investigative proceedings, and the availability of financing.
These and other risks and uncertainties are detailed in Fresenius Medical
Care AG & Co. KGaA's reports filed with the U.S. Securities and Exchange
Commission. Fresenius Medical Care AG & Co. KGaA does not undertake any
responsibility to update the forward-looking statements in this release.
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30.07.2018 Dissemination of a Corporate News, transmitted by DGAP - a
service of EQS Group AG.
The issuer is solely responsible for the content of this announcement.
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Language: English
Company: Fresenius Medical Care AG & Co. KGaA
Else-Kröner-Straße 1
61352 Bad Homburg
Germany
Phone: +49 (0) 6172- 609 2525
Fax: +49 (0) 6172- 609 2301
E-mail: [email protected]
Internet: www.freseniusmedicalcare.com
ISIN: DE0005785802
WKN: 578580
Indices: DAX
Listed: Regulated Market in Frankfurt (Prime Standard); Regulated
Unofficial Market in Berlin, Dusseldorf, Hamburg, Hanover,
Munich, Stuttgart, Tradegate Exchange; NYSE
End of News DGAP News Service
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709039 30.07.2018
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