26.10.2016
WILEX AG DE000A11QVV0
DGAP-News: WILEX AG: Subsidiary Heidelberg Pharma and Nordic Nanovector Enter into Collaboration to Develop Novel Antibody Drug Conjugates (ADC)
DGAP-News: WILEX AG / Key word(s): Alliance
WILEX AG: Subsidiary Heidelberg Pharma and Nordic Nanovector Enter into
Collaboration to Develop Novel Antibody Drug Conjugates (ADC)
26.10.2016 / 07:00
The issuer is solely responsible for the content of this announcement.
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PRESS RELEASE
WILEX AG: Subsidiary Heidelberg Pharma and Nordic Nanovector Enter into
Collaboration to Develop Novel Antibody Drug Conjugates (ADC)
Munich, Germany, 26 October 2016 - WILEX AG (ISIN DE000A11QVV0 / WL6 / FSE)
today announced that its subsidiary Heidelberg Pharma GmbH, Ladenburg,
Germany, entered into a research collaboration with Nordic Nanovector ASA,
Oslo, Norway (Ticker: NANO), a biotech company focusing on the development
and commercialization of novel targeted therapeutics in hematology and
oncology. The collaboration aims at developing novel antibody drug
conjugates (ADCs) to treat leukemias. Leukemias are orphan diseases with a
significant unmet medical need, applicable indications representing a
growing market worth over USD 5 billion by 2020 .
Professor Dr Andreas Pahl, Head of Research & Development and member of the
Management Board of WILEX and Heidelberg Pharma, commented: "The project
extends our ADC portfolio to additional hematological cancers. Nordic
Nanovector has an established chemistry, manufacturing, and controls (CMC)
process for their antibody which will speed up processes and reduce the
development costs of the ADCs."
Jostein Dahle, Nordic Nanovector's Chief Scientific Officer, added: "We are
pleased to further expand our R&D activities into the ADC area with
Heidelberg Pharma. During the past year, we have made important steps to
execute our strategy designed to build a pipeline of innovative antibody-
radionuclide conjugates (ARCs) and ADCs that combine our expertise and
platform with complementary technologies from expert partners."
About WILEX and Heidelberg Pharma's proprietary ATAC technology
WILEX AG is a biopharmaceutical company based in Munich, Germany, that
serves as a parent and holding company. The Company's research and
development work is conducted by its subsidiary, Heidelberg Pharma GmbH in
Ladenburg. Heidelberg Pharma is focused on developing an innovative ADC
technology platform based on the compound Amanitin (ATAC technology) and
also provides preclinical drug research and development services.
Antibody drug conjugates (ADCs) combine the high affinity and specificity
of antibodies with the potency of cytotoxic small molecules for the
treatment of cancer and inflammatory diseases. ATACs are ADCs that are
bound to highly potent amatoxin molecules. Amatoxins are small bicyclic
peptides naturally occurring in the death cap mushroom. They inhibit mRNA
transcription by binding to RNA polymerase II, a mechanism that is crucial
for the survival of eukaryotic cells. In preclinical testing, ATACs have
been shown to be highly efficacious, overcoming frequently encountered
resistance mechanisms and combatting even quiescent tumor cells.
Heidelberg Pharma is working on several ATAC candidates with industry
partners as well as on its own ATAC pipeline. The lead candidate HDP-101, a
BCMA ATAC, has been selected for the preclinical and clinical development
in multiple myeloma, the third most common hematologic cancer.
WILEX has diagnostic and therapeutic Phase III drug candidates, which are
available for out-licensing. WILEX is listed at the Frankfurt Stock
Exchange: ISIN DE000A11QVV0 / WKN A11QVV / Symbol WL6. More information is
available at www.wilex.com and www.heidelberg-pharma.com.
About Nordic Nanovector
Nordic Nanovector is a biotech company focusing on the development and
commercialization of novel targeted therapeutics in hematology and
oncology. The Company's lead clinical-stage product opportunity is
Betalutin(R), the first in a new class of Antibody-Radionuclide-Conjugates
(ARC) designed to improve upon and complement current options for the
treatment of non-Hodgkin Lymphoma (NHL). NHL is an indication with
substantial unmet medical need and orphan drug opportunities, representing
a growing market worth over $12 billion by 2018.
Betalutin(R) comprises a tumor-seeking anti-CD37 antibody, lilotomab
(previously referred to as HH1), conjugated to a low intensity radionuclide
(lutetium-177). The preliminary data has shown promising efficacy and
safety profile in an ongoing Phase 1/2 study in a difficult-to-treat NHL
patient population. The Company is aiming at developing Betalutin(R) for
the treatment of major types of NHL with first regulatory submission
anticipated in 1H 2019.
Nordic Nanovector intends to retain marketing rights and to actively
participate in the commercialization of Betalutin(R) in core markets, while
exploring potential distribution agreements in selected geographies. The
Company is committed to developing its ARC pipeline to treat multiple
selected cancer indications.
Further information about the Company can be found at
www.nordicnanovector.com
This information is subject to the disclose requirements pursuant to
section 5-12 of the Norwegian Securities Trading Act.
Contact IR/PR support WILEX AG MC Services AG Sylvia Wimmer Katja Arnold (CIRO) Corporate Communications Managing Director & Partner Tel.: +49 (0)89-41 31 38-29 Tel.: +49 (0)89-210 228-40 Email: investors[at]wilex.com Mobile: +49 (0)160 9360 3022 Grillparzerstr. 18, 81675 Munich Email: katja.arnold[at]mc-services.eu For Nordic Nanovector Media enquiries: IR enquiries: Mark Swallow/David Dible (Citigate Dewe Luigi Costa, Chief Executive Rogerson) Officer Tel: +44 207 282 2948/+44 207 282 2949 Cell: +41 79 124 8601 Email: Tone Kvåle, Chief Financial nordicnanovector[at]citigatedr.co.uk Officer Cell: +47 91 51 95 76 Email: ir[at]nordicnanovector.comThis communication contains certain forward-looking statements relating to the Company's business, which can be identified by the use of forward- looking terminology such as "estimates", "believes", "expects", "may", "will" "should" "future", "potential" or similar expressions or by a general discussion of the Company's strategy, plans or intentions. Such forward-looking statements involve known and unknown risks, uncertainties and other factors, which may cause our actual results of operations, financial condition, performance, or achievements, or industry results, to be materially different from any future results, performance or achievements expressed or implied by such forward-looking statements. Given these uncertainties, prospective investors and partners are cautioned not to place undue reliance on such forward-looking statements. We disclaim any obligation to update any such forward-looking statements to reflect future events or developments. --------------------------------------------------------------------------- 26.10.2016 Dissemination of a Corporate News, transmitted by DGAP - a service of EQS Group AG. The issuer is solely responsible for the content of this announcement. The DGAP Distribution Services include Regulatory Announcements, Financial/Corporate News and Press Releases. Archive at www.dgap.de --------------------------------------------------------------------------- Language: English Company: WILEX AG Grillparzerstr. 18 81675 München Germany Phone: +49 (0)89 41 31 38 - 0 Fax: +49 (0)89 41 31 38 - 99 E-mail: [email protected] Internet: www.wilex.com ISIN: DE000A11QVV0 WKN: A11QVV Listed: Regulated Market in Frankfurt (Prime Standard); Regulated Unofficial Market in Berlin, Dusseldorf, Munich, Stuttgart, Tradegate Exchange End of News DGAP News Service --------------------------------------------------------------------------- 514599 26.10.2016
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