28.06.2016 WILEX AG  DE000A11QVV0

DGAP-News: WILEX AG: European Patent Office grants patent for the chemical synthetic building block dihydroxyisoleucine for the production of Amanitin


 
DGAP-News: WILEX AG / Key word(s): Patent WILEX AG: European Patent Office grants patent for the chemical synthetic building block dihydroxyisoleucine for the production of Amanitin 28.06.2016 / 07:30 The issuer is solely responsible for the content of this announcement. --------------------------------------------------------------------------- PRESS RELEASE WILEX AG: European Patent Office grants patent for the chemical synthetic building block dihydroxyisoleucine for the production of Amanitin - Patent grant supports the synthetic production of Amanitin Munich, Germany, 28 June 2016 - WILEX AG (ISIN DE000A11QVV0 / WL6 / FSE) today announced that its subsidiary Heidelberg Pharma GmbH has been granted a patent by the European Patent Office (EPO) for the chemical synthesis of dihydroxyisoleucine developed by it. The patent has a term until 2033. The amino acid dihydroxyisoleucine is an important synthetic building block of alpha-Amanitin and of Amanitin derivatives. Without this building block it is not possible to chemically produce Amanitin. Dihydroxyisoleucine, on the other hand, has to be chemically produced, as there is no natural source of it. The patent protects the company's internal Amanitin production process, since the production of adequate quantities of Amanitin in GMP quality for clinical use can only be ensured by a completely chemical production of Amanitin. After being bound to a linker and conjugated with antibodies, alpha-Amanitin and its derivatives are used in the ATAC technology pursued by Heidelberg Pharma. Professor Andreas Pahl, Head of Research and Development and member of the Executive Management Board of WILEX AG, comments: "We are very pleased that this patent has been granted, because it protects an important building block of our synthetic Amanitin production. It strengthens our position as the first company worldwide to use the highly effective and innovative compound Amanitin for ADC technology. We will continue to focus our efforts on the full chemical production of Amanitin." About Heidelberg Pharma's proprietary ATAC technology Antibody drug conjugates (ADCs) combine the high affinity and specificity of antibodies with the potential of small cytotoxic molecules for the treatment of cancer and inflammatory diseases. ATACs are ADCs that are bound to highly potent amatoxin molecules. Amatoxins are small bicyclic peptides naturally occurring in the death cap mushroom. They inhibit mRNA transcription by binding to RNA polymerase II, a mechanism that is crucial for the survival of eukaryotic cells. Accordingly, ATACs exhibit comparable activity against proliferating and quiescent tumour cells. This proliferation independent activity differentiates ATACs from other ADCs, which preferentially target proliferating tumour cells. As a potential additional advantage ATACs could offer a substantial capability to overcome the resistance mechanisms which might limit the efficacy of other antibody drug conjugates. About WILEX and Heidelberg Pharma WILEX AG is a biopharmaceutical company acting as a holding company and Group parent. Research and development focus on the operations of its subsidiary Heidelberg Pharma GmbH in Ladenburg, which primarily advances the development of the innovative ADC platform technology for antibody-drug conjugates based on the compound Amanitin (ATAC technology) and provides preclinical drug research and development services. WILEX has diagnostic and therapeutic Phase-III drug candidates, which are available for out- licensing to external partners. WILEX is listed at the Frankfurt Stock Exchange: ISIN DE000A11QVV0 / WKN A11QVV / Symbol WL6. More information is available at www.wilex.com
Contact                           IR/PR support
WILEX AG                          MC Services AG
Sylvia Wimmer                     Katja Arnold (CIRO)
Corporate Communications          Executive Director & Partner
Tel.: +49 (0)89-41 31 38-29       Tel.: +49 (0)89-210 228-40
E-Mail: investors[at]wilex.com    Mobil: +49 (0)160 9360 3022
Grillparzerstr. 18, 81675         E-Mail: katja.arnold[at]mc-services.eu
Munich, Germany
Business Development
Heidelberg Pharma GmbH
Dr Marcel Linssen
CBO, Executive Vice President
Tel.: +49 (0)6203-1009-40
E-Mail: m.linssen[at]hdpharma.com
This communication contains certain forward-looking statements relating to the Company's business, which can be identified by the use of forward- looking terminology such as "estimates", "believes", "expects", "may", "will", "should", "future", "potential" or similar expressions or by a general discussion of the Company's strategy, plans or intentions. Such forward-looking statements involve known and unknown risks, uncertainties and other factors, which may cause our actual results of operations, financial position, earnings, achievements, or industry results, to be materially different from any future results, earnings or achievements expressed or implied by such forward-looking statements. Given these uncertainties, prospective investors and partners are cautioned not to place undue reliance on such forward-looking statements. We disclaim any obligation to update any such forward- looking statements to reflect future events or developments. --------------------------------------------------------------------------- 28.06.2016 Dissemination of a Corporate News, transmitted by DGAP - a service of EQS Group AG. The issuer is solely responsible for the content of this announcement. The DGAP Distribution Services include Regulatory Announcements, Financial/Corporate News and Press Releases. Archive at www.dgap.de --------------------------------------------------------------------------- Language: English Company: WILEX AG Grillparzerstr. 18 81675 München Germany Phone: +49 (0)89 41 31 38 - 0 Fax: +49 (0)89 41 31 38 - 99 E-mail: [email protected] Internet: www.wilex.com ISIN: DE000A11QVV0 WKN: A11QVV Listed: Regulated Market in Frankfurt (Prime Standard); Regulated Unofficial Market in Berlin, Dusseldorf, Munich, Stuttgart End of News DGAP News Service --------------------------------------------------------------------------- 474543 28.06.2016


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INVESTOR-INFORMATIONEN
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Heidelberg Pharma
WKN Kurs in € Einschätzung Börsenwert in Mio. €
A11QVV 3,070 Halten 143,08
KGV 2025e KGV 10Y-Ø BGFL-Ratio Shiller-KGV
0,00 0,00 0,00 -5,58
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2,90 - 14,51 -5,18
Dividende '22 in € Dividende '23e in € Div.-Rendite '23e
in %
Hauptversammlung
0,00 0,00 0,00 20.06.2024
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25.04.2024 11.07.2024 10.10.2024 25.03.2024
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Biotechnologie , A11QVV , HPHA , XETR:WL6